STEMCELL Technologies U-0126

MEK/ERK pathway inhibitor; Inhibits MEK1 and MEK2

Brand:  STEMCELL Technologies 73524

Product Code. 17100242

Description

• U-0126 is a selective, non-ATP competitive inhibitor of mitogen activated protein kinase kinase (MEK), inhibiting MEK1 and MEK2 with IC₅₀ values of 72 nM and 58 nM, respectively (Favata et al.; Scherle et al.) It shows little or no inhibition at micromolar levels of other kinases such as ERK, protein kinase C (PKC), c-Jun N-terminal kinases (JNK), other MAP kinase kinases (MKK3, MKK4, MKK6), cyclin-dependent kinases (CDK2, CDK4), ABL, and RAF (Favata et al.) 1998)
• U-0126 also antagonizes AP-1 transcription and selectively inhibits promoters containing AP-1 response elements (Favata et al.)

Specifications

• CAS: 109511-58-2
• Quantity: 10 mg
• Molecular Formula: C₁₈H₁₆N₆S₂
• Purity: ≥98%