Invitrogen™ Tyrosine Hydroxylase Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ P21962

Product Code. 11370672

Description

Tyrosine Hydroxylase Polyclonal Antibody for Western Blot, IHC (F), ICC/IF

Tyrosine hydroxylase (TH) is an enzyme involved in the synthesis of catecholamine neurotransmitters dopamine, epinephrine, and norepinephrine. In all species, catecholamine synthesis is regulated by the interaction of TH with a cofactor, tetrahydrobiopterin (BH4). BH4 binds to the TH catalytic domain, resulting in enzymatic activity. Unlike TH in non-primate species, four human TH mRNA splice variants (hTH1-hTH4) have been isolated. These variants are identical in their catalytic domain, but differ in their N-terminal, regulatory domains. TH is also responsible for the conversion of L-tyrosine to L-dopa. TH plays a key role in the physiology of adrenergic neurons. The role of TH in the synthesis of catecholamine neurotransmitters suggests a correlation between the enzyme and a number of neuropathogenic diseases including: Parkinson's disease, schizophrenia, Segawa syndrome, and dystonia, as well as a variety of cardiovascular diseases.

Specifications

• Antigen: Tyrosine Hydroxylase
• Classification: Polyclonal
• Formulation: 0.01M HEPES with 100μg/mL BSA, 50% glycerol, 0.15M NaCl and no preservative; pH 7.5
• Gene Accession No.: P04177, P07101
• Gene Symbols: TH
• Immunogen: SDS-denatured rat tyrosine hydroxylase, purified from pheochromocytoma.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Rat
• Product Type: Antibody
• Isotype: IgG

• Applications: Immunohistochemistry (Frozen), Western Blot, Immunocytochemistry
• Conjugate: Unconjugated
• Gene: TH
• Gene Alias: dystonia 14; DYT14; DYT5b; EC 1.14.16.2; HGNC:11782; Th; TH isoform 3; TH isoform a; th1; TH-4; The; TY3H; TYH; TYH antibody; Tyrosine 3-hydroxylase; tyrosine 3-monooxygenase; tyrosine hydroxylase
• Host Species: Rabbit
• Purification Method: Purified
• Regulatory Status: RUO
• Gene ID (Entrez): 25085, 7054
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid
• Green Features: Responsibly packaged