Invitrogen™ TWEAK Monoclonal Antibody (CARL-1)

Mouse Monoclonal Antibody

Brand:  Invitrogen™ MA528604

Product Code. 16362864

Description

This antibody recognizes an extracellular epitope of CD255 / TWEAK, a type II transmembrane protein of the TNF superfamily able to induce apoptosis weakly in many cell types. Functional Application: Neutralization.

TNF-related weak inducer of apoptosis (TWEAK) is a member of the tumor necrosis factor superfamily (TNFSF) of structurally related cytokines. Like most other members of this family, TWEAK is a cell surface-associated type II transmembrane protein although a smaller, biologically active form can also be generated by cleavage near the cell membrane. TWEAK has multiple biological activities, including stimulation of cell growth and angiogenesis, induction of inflammatory cytokines, in addition to stimulation of apoptosis. The TWEAK signal transduction pathway has not been well established but it appears to signal via TweakR/Fn14 in a manner similar to that described for other TNFSF members that bind receptors lacking death domains.

Specifications

• Antigen: TWEAK
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: TBS with no preservative; pH 8.0
• Gene Accession No.: O43508
• Gene Symbols: Tnfsf12
• Immunogen: human CD255-transfected 2PK-3 cells.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG3 κ

• Applications: Flow Cytometry, Functional Assay, Immunohistochemistry
• Clone: CARL-1
• Conjugate: Unconjugated
• Gene: Tnfsf12
• Gene Alias: APO3 ligand; APO3/DR3 ligand; APO3L; Dr3l; Dr3lg; LOW QUALITY PROTEIN: tumor necrosis factor ligand superfamily member 12; MGC129581; MGC20669; TNF superfamily member 12; TNF-related weak inducer of apoptosis; TNFSF12; TNLG4A; tumor necrosis factor (ligand) superfamily member 12; tumor necrosis factor (ligand) superfamily, member 12; tumor necrosis factor ligand 4A; tumor necrosis factor ligand superfamily member 12; Tumor necrosis factor ligand superfamily member 12, membrane form; Tumor necrosis factor ligand superfamily member 12, secreted form; tumor necrosis factor superfamily member 12; TWEAK; UNQ181/PRO207; zgc:153941
• Host Species: Mouse
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 8742
• Content And Storage: 4°C, do not freeze
• Form: Liquid