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  6. Melford Tunicamycin

Melford Tunicamycin

Product Code. 30018834
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Quantity:
10 mg
50 mg
Unit Size:
10mg
50mg
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Product Code. 30018834

Brand: Melford T225000.05

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This item is not returnable. View return policy

Description

Tunicamycin is a nucleoside antibiotic that inhibits the biosynthesis of N-linked glycoproteins.

Tunicamycin is a nucleoside antibiotic that inhibits the biosynthesis of N-linked glycoproteins. It inhibits the formation of N-glycosidic linkages during the early steps of protein glycosylation. Also, it interferes with the transfer of N-acetylglucosamine-1-phosphate to dolichol phosphate, a crucial step in the synthesis of lipid-linked oligosaccharides. As a result, the glycosylation process in the endoplasmic reticulum is disrupted.

Widely used as a tool in cell biology and biochemistry to study protein glycosylation. It helps researchers investigate the effects of impaired glycosylation on cellular processes. This antibiotic induces endoplasmic reticulum (ER) stress by disrupting protein folding and glycosylation in the ER. This property is utilized in studies focused on understanding ER stress responses and unfolded protein response pathways.

Tunicamycin is a valuable tool for investigating the role of protein glycosylation in cellular functions and for inducing ER stress for studies related to unfolded protein responses.

Specifications

Chemical Name or Material Tunicamycin
CAS 11089-65-9
Quantity 50 mg
Molecular Formula C39H64N4O16
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