Invitrogen™ TTBK2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA534369

Product Code. 15345301

Description

PA5-34369 can be used with blocking peptide PEP-1412.

Tau tubulin kinase (TTBK2) is a serine/threonine kinase whose substrates are thought to include the tau and tubulin proteins. Mutations in the TTBK2 gene cause spinocerebellar ataxia type 11 (SCA11), a neurodegenerative disease characterized by progressive ataxia and atrophy of the cerebellum and brainstem. Recent studies have shown that increased levels of TTBK2 expression in kidney carcinoma and melanoma cell lines increases resistance to the chemotherapeutic agent Sunitinib, and that reduction of TTBK2 though the use of siRNA sensitized these cell lines to the effects of Sunitib, suggesting that TTBK2 can be used as a resistance marker as well a potential target to overcome resistance.

Specifications

• Antigen: TTBK2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: TTBK2
• Gene Alias: 2610507N02Rik; AI326283; B930008N24Rik; Bby; KIAA0847; mKIAA0847; Protein bartleby; SCA11; tau tubulin kinase 1; tau tubulin kinase 2; tau-tubulin kinase 2; Ttbk; Ttbk1; TTBK2; TTK
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 146057
• Content And Storage: Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
• Form: Liquid

• Applications: Immunohistochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 0.02% sodium azide
• Gene Accession No.: Q6IQ55
• Gene Symbols: TTBK2
• Immunogen: An 18 amino acid synthetic peptide near the carboxy terminus of human TTBK2.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG