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Invitrogen™ TSLP Receptor Polyclonal Antibody

Product Code. 12858562
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Quantity:
100 μg
Unit Size:
100µg
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12858562 100 μg 100µg
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Product Code. 12858562 Supplier Invitrogen™ Supplier No. PA520378

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Description

Rabbit Polyclonal Antibody

Despite its predicted molecular weight, TSLP-R often migrates at a higher molecular weight in SDS-PAGE. A suggested positive control is human liver tissue lysate. PA5-20378 can be used with blocking peptide PEP-0495.

Thymic stromal lymphopoietin (TSLP) has recently been identified as an important factor capable of driving dendritic cell maturation and activation. It is involved in the positive selection of regulatory T cells, maintenance of peripheral CD4+ T cell homeostasis and the induction of CD4+ T cell-mediated allergic reaction. TSLP is also capable of supporting the growth of fetal liver and adult B cell progenitors and their differentiation to the IgM-positive stage of B cell development. Its receptor TSLP-R will bind TSLP in a low-affinity fashion in transfected cells; co-transfection with IL-7R-alpha cDNA results in high-affinity binding and a functional heteromeric complex. This heteromeric receptor requires stat5 for TSLP-mediated signal transduction and is inhibited by SOCS-1.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TSLP Receptor
Applications Immunohistochemistry, Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene CRLF2
Gene Accession No. Q9HC73
Gene Alias CRL2; Crlf2; CRLF2Y; Crlm2; CRLM-2; cytokine receptor CRL2 precusor; Cytokine receptor-like 2; Cytokine receptor-like factor 2; cytokine receptor-like molecule 2; delta 1; ILXR; IL-XR; Ly114; lymphocyte antigen 114; P2RY8/CRLF2 fusion; thymic stromal lymphopoietin protein receptor; thymic stromal-derived lymphopoietin receptor; thymic stromal-derived lymphopoietin, receptor; Tpte2; transmembrane phosphoinositide 3-phosphatase and tensin homolog 2; TSLP receptor; Tslpr; type I cytokine receptor delta 1; WI2-87105E3.1
Gene Symbols CRLF2
Host Species Rabbit
Immunogen A 19 amino acid peptide from near the center of human TSLP receptor.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 64109
Target Species Human
Content And Storage Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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