TSLP Rat anti-Mouse, Clone: eBio28F12 (28F12), Functional Grade, eBioscience™

Rat Monoclonal Antibody, Functional Grade

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 16-5491-85

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.01000kg



Disclaimers: For Research Use Only.

Product Code. 15268647

Quantity Price
1 £ 219.5 / 500µg
EU Stock 1
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Description and Specification

Specification

Antigen TSLP
Applications Cytokine Neutralization
Clone eBio28F12 (28F12)
Concentration 1mg/mL
Conjugate Unlabeled
Format Purified
Formulation aqueous buffer, no sodium azide
Gene Alias thymic stromal derived lymphopoietin
Host Species Rat
Isotype IgG2a
Quantity 500μg
Regulatory Status RUO
Storage Requirements Store at 2-8°C.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Target Species Murine

The monoclonal antibody eBio28F12 reacts with and inhibits the bioactivity of mouse TSLP. Thymic Stromal-Derived Lymphopoetin (TSLP) was first identified in the tissue culture supernatant of a thymic stromal cell line as a growth factor capable of inducing proliferation and differentiation of pre-B cells. It was later found to be closely related to another stromal cytokine, IL-7, with which it shares overlapping functions. Along with its proliferative effects on B cells, TSLP induces dendritic cells to support the differentiation of naïve T cells towards the Th2 lineage and may also be involved in the development of CD4+CD25+ regulatory T cells. The receptor for TSLP is heterodimeric and shares one subunit, IL-7Rα, with IL-7 and other members of the family, while the TSLPR subunit is unique to TSLP.

TSLP expression can be induced by a variety of inflammatory cytokines and TLR ligands. Expression is regulated by NF-κB and has been detected in epithelial cells, stromal cells, and basophils. Elevated levels of TSLP are associated with asthma and atopic dermatitis, which are both Th2-mediated inflammatory conditions. It is believed that chronic overexpression of TSLP may result in increased sensitivity to allergens, resulting in susceptibility to these conditions.