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Invitrogen™ TSKU Polyclonal Antibody
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Product Code. 15770471 Shop All Thermo Scientific Products
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100 μL
Unit Size:
100µL
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15770471 100 μL 100µL
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Product Code. 15770471 Supplier Invitrogen™ Supplier No. PA552523

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Description

Rabbit Polyclonal Antibody

Immunogen sequence: DTAHLDLSSN RLEMVNESVL AGPGYTTLAG LDLSHNLLTS ISPTAFSRLR YLESLDLSHN GLTALPAESF TSSPLSDVNL SHNQLREVSV SAFTTHSQGR ALHVDLSHNL IHR Highest antigen sequence identity to the following orthologs: Mouse - 92%, Rat - 93%.

The TSKU gene encodes Tsukushi, a member of the small leucine-rich proteoglycan (SLRP) family, playing crucial roles in cellular signaling, growth, and development. Tsukushi is characterized by its involvement in various biological processes, including immune regulation, tissue remodeling, and metabolic homeostasis. It is a hepatokine released in response to conditions like nonalcoholic fatty liver disease (NAFLD), influencing metabolic traits and contributing to conditions such as dyslipidemia and cardiovascular diseases. Tsukushi impacts energy expenditure by modulating brown fat thermogenesis, thereby affecting metabolic homeostasis and obesity-related metabolic traits. As an extracellular matrix component, Tsukushi participates in signaling pathways that regulate cell proliferation, migration, and differentiation, impacting organ development and pathophysiological processes. Its role in metabolic and inflammatory diseases presents it as a potential biomarker and therapeutic target in conditions characterized by altered metabolic and inflammatory states. Ongoing research further elucidates Tsukushi's mechanisms and interactions, contributing to our understanding of its multifunctional roles in health and disease.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TSKU
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.1 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene TSKU
Gene Accession No. Q6QMY6, Q8CBR6, Q8WUA8
Gene Alias 9530051K01Rik; E2ig4; E2-induced gene 4 protein; Early insulin-induced hepatic gene protein; Eiih; hepatic protein EIIH; leucine rich repeat containing 54; leucine-rich repeat-containing protein 54; LRRC54; Tsk; Tsku; Tsukushi; tsukushi homolog; tsukushi small leucine rich proteoglycan homolog; tsukushi, small leucine rich proteoglycan; tsukushin; UNQ850/PRO1788
Gene Symbols TSKU
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human TSKU. Recombinant protein control fragment (Product #RP-89879).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 244152, 25987, 308843
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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