Invitrogen™ TSKU Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA552523

Product Code. 15770471

Description

Immunogen sequence: DTAHLDLSSN RLEMVNESVL AGPGYTTLAG LDLSHNLLTS ISPTAFSRLR YLESLDLSHN GLTALPAESF TSSPLSDVNL SHNQLREVSV SAFTTHSQGR ALHVDLSHNL IHR Highest antigen sequence identity to the following orthologs: Mouse - 92%, Rat - 93%.

The TSKU gene encodes Tsukushi, a member of the small leucine-rich proteoglycan (SLRP) family, playing crucial roles in cellular signaling, growth, and development. Tsukushi is characterized by its involvement in various biological processes, including immune regulation, tissue remodeling, and metabolic homeostasis. It is a hepatokine released in response to conditions like nonalcoholic fatty liver disease (NAFLD), influencing metabolic traits and contributing to conditions such as dyslipidemia and cardiovascular diseases. Tsukushi impacts energy expenditure by modulating brown fat thermogenesis, thereby affecting metabolic homeostasis and obesity-related metabolic traits. As an extracellular matrix component, Tsukushi participates in signaling pathways that regulate cell proliferation, migration, and differentiation, impacting organ development and pathophysiological processes. Its role in metabolic and inflammatory diseases presents it as a potential biomarker and therapeutic target in conditions characterized by altered metabolic and inflammatory states. Ongoing research further elucidates Tsukushi's mechanisms and interactions, contributing to our understanding of its multifunctional roles in health and disease.

Specifications

• Antigen: TSKU
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: TSKU
• Gene Alias: 9530051K01Rik; E2ig4; E2-induced gene 4 protein; Early insulin-induced hepatic gene protein; Eiih; hepatic protein EIIH; leucine rich repeat containing 54; leucine-rich repeat-containing protein 54; LRRC54; Tsk; Tsku; Tsukushi; tsukushi homolog; tsukushi small leucine rich proteoglycan homolog; tsukushi, small leucine rich proteoglycan; tsukushin; UNQ850/PRO1788
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 244152, 25987, 308843
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 0.1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q6QMY6, Q8CBR6, Q8WUA8
• Gene Symbols: TSKU
• Immunogen: Recombinant protein corresponding to Human TSKU. Recombinant protein control fragment (Product #RP-89879).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG