Invitrogen™ TSKU Monoclonal Antibody (462310)

Rat Monoclonal Antibody

Brand:  Invitrogen™ MA524182

Product Code. 15553872

Description

In direct ELISAs and Western blots, approximately 25% cross-reactivity with recombinant human Tsukushi/TSK is observed. Reconstitute in sterile PBS to a final concentration of 0.5 mg/mL.

The TSKU gene encodes Tsukushi, a member of the small leucine-rich proteoglycan (SLRP) family, playing crucial roles in cellular signaling, growth, and development. Tsukushi is characterized by its involvement in various biological processes, including immune regulation, tissue remodeling, and metabolic homeostasis. It is a hepatokine released in response to conditions like nonalcoholic fatty liver disease (NAFLD), influencing metabolic traits and contributing to conditions such as dyslipidemia and cardiovascular diseases. Tsukushi impacts energy expenditure by modulating brown fat thermogenesis, thereby affecting metabolic homeostasis and obesity-related metabolic traits. As an extracellular matrix component, Tsukushi participates in signaling pathways that regulate cell proliferation, migration, and differentiation, impacting organ development and pathophysiological processes. Its role in metabolic and inflammatory diseases presents it as a potential biomarker and therapeutic target in conditions characterized by altered metabolic and inflammatory states. Ongoing research further elucidates Tsukushi's mechanisms and interactions, contributing to our understanding of its multifunctional roles in health and disease.

Specifications

• Antigen: TSKU
• Classification: Monoclonal
• Concentration: 0.5 mg/mL
• Formulation: PBS with 5% trehalose and No Preservative
• Gene Accession No.: Q8CBR6
• Gene Symbols: TSKU
• Immunogen: Mouse myeloma cell line NS0-derived recombinant mouse Tsukushi/TSK Thr18-Leu354.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Mouse
• Product Type: Antibody
• Isotype: IgG2c

• Applications: Western Blot
• Clone: 462310
• Conjugate: Unconjugated
• Gene: TSKU
• Gene Alias: 9530051K01Rik; E2ig4; E2-induced gene 4 protein; Early insulin-induced hepatic gene protein; Eiih; hepatic protein EIIH; leucine rich repeat containing 54; leucine-rich repeat-containing protein 54; LRRC54; Tsk; Tsku; Tsukushi; tsukushi homolog; tsukushi small leucine rich proteoglycan homolog; tsukushi, small leucine rich proteoglycan; tsukushin; UNQ850/PRO1788
• Host Species: Rat
• Purification Method: Protein A/G
• Regulatory Status: RUO
• Gene ID (Entrez): 244152
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized