Invitrogen™ Trypsin 2 Recombinant Rabbit Monoclonal Antibody (3D9O7)

Rabbit Recombinant Monoclonal Antibody

Brand:  Invitrogen™ MA537902

Product Code. 17206783

Description

Positive Samples: Mouse pancreas, Rat pancreas Immunogen sequence: MNLLLILTFV AAAVAAPFDD DDKIVGGYIC EENSVPYQVS LNSGYHFCGG SLISEQWVVS AGHCYKSRIQ VRLGEHNIEV LEGNEQFINA AKIIRHPKYN.

This gene belongs to the trypsin family of serine proteases and encodes anionic trypsinogen. It is part of a cluster of trypsinogen genes that are located within the T cell receptor beta locus. Enzymes of this family cleave peptide bonds that follow lysine or arginine residues. This protein is found at high levels in pancreatic juice and its upregulation is a characteristic feature of pancreatitis. This protein has also been found to activate pro-urokinase in ovarian tumors, suggesting a function in tumor invasion. In addition, this enzyme is able to cleave across the type II collagen triple helix in rheumatoid arthritis synovitis tissue, potentially participating in the degradation of type II collagen-rich cartilage matrix. Alternative splicing results in multiple transcript variants.

Specifications

• Antigen: Trypsin 2
• Classification: Recombinant Monoclonal
• Concentration: 0.33 mg/mL
• Formulation: PBS with 50% glycerol, 0.05% BSA and 0.02% sodium azide; pH 7.3
• Gene Accession No.: P00763, P07146, P07478
• Gene Symbols: PRSS2
• Immunogen: Synthetic peptide.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot
• Clone: 3D9O7
• Conjugate: Unconjugated
• Gene: PRSS2
• Gene Alias: anionic trypsin; anionic trypsin II; Anionic trypsin-2; anionic trypsinogen; EC 3.4.21; EC 3.4.21.4; MGC111183; MGC120174; MGC120175; pancreatic anionic trypsinogen; pancreatic trypsin 2; pancreatic trypsin II; pretrypsinogen II; protease serine 2 preproprotein; protease, serine 2; protease, serine, 2; protease, serine, 2 (trypsin 2); PRSS2; Ptryss2; Serine protease 2; Ta; Tesp4; Try2; TRY8; TRYP; TRYP2; TRYP8; trypsin 2; trypsin II; trypsin Trypsin II; Trypsin-2; trypsinogen 2; trypsinogen 20; trypsinogen anionic precursor
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 22072, 25052, 5645
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid