Invitrogen™ TrxR2 Recombinant Rabbit Monoclonal Antibody (23GB4925), Invitrogen™

Rabbit Recombinant Monoclonal Antibody

Brand:  Invitrogen™ MA553835

Product Code. 30089231

Description

The mammalian thioredoxin reductases (TrxRs) are a family of selenocysteine-containing pyridine nucleotide-disulfide oxidoreductases. All the mammalian TrxRs are homologous to glutathione reductase with respect to primary structure including the conserved redox catalytic site (-Cys-Val-Asn-Val-Gly-Cys-) but distinctively with a C-terminal extension containing a catalytically active penultimate selenocysteine (SeCys) residue in the conserved sequence (-Gly-Cys-SeCys-Gly). TrxR is homodimeric protein in which each monomer includes an FAD prosthetic group, a NADPH binding site and a redox catalytic site. Electrons are transferred from NADPH via FAD and the active-site disulfide to C-terminal SeCys-containing redox center, which then reduces the substrate like thioredoxin. The members of TrxR family are 55-58 kilodalton in molecular size and composed of three isoforms including cytosolic TrxR1, mitochondrial TrxR2, and TrxR3, known as Trx and GSSG reductase (TGR). TrxR plays a key role in protection of cells against oxidative stress and redox-regulatory mechanism of transcription factors and various biological phenomena.

Specifications

• Antigen: TrxR2
• Classification: Recombinant Monoclonal
• Conjugate: Unconjugated
• Gene: TXNRD2
• Gene Alias: AA118373; ESTM573010; KIAA1652; Selenoprotein Z; SelZ; TGR; thioredoxin reductase 2; thioredoxin reductase 2, mitochondrial; thioredoxin reductase 3; thioredoxin reductase beta; thioredoxin reductase TR3; TR; TR beta; TR3; TR-BETA; Trxr2; Trxrd2; TXNRD2
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 10587
• Content And Storage: -20°C
• Form: Liquid

• Applications: Flow Cytometry, Western Blot, Immunocytochemistry
• Clone: 23GB4925
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: Q9NNW7
• Gene Symbols: TXNRD2
• Immunogen: A synthesized peptide derived from human TXNRD2 (50-100AA).
• Quantity: 20 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG