TRPV2 (extracellular) Polyclonal Antibody, Invitrogen™

Guinea Pig Polyclonal Antibody

Brand:  Invitrogen PA5111808

Product Code. 17139723

Description

Reconstitute antibody with 50 μL of double distilled water (DDW). The reconstituted solution can be stored at 4 degrees C for up to 1 week. For longer periods, small aliquots should be stored at -20 degrees C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min). Peptide sequence is: (C)HQPSLDQ PAIPSSKAT Homology: Mouse - 15/16.Human - will not recognize the human epitope.

VLR-1 is a calcium-permeable, non-selective cation channel with an outward rectification, that seems to be regulated, at least in part, by growth factors, like IGF1, PDGF and morphogenetic neuropeptide/head activator. VRL-1 does not respond to capsaicin, acid, or moderate heat, but instead is activated by high temperatures, with a threshold of approximately 52 degrees C. Within sensory ganglia, VRL-1 is most prominently expressed by a subset of medium- to large-diameter neurons, making it a candidate receptor for transducing high-threshold heat responses in this class of cells. VRL-1 transcripts are not restricted to the sensory nervous system, indicating that this channel may be activated by stimuli other than heat. VRL-1 is one of the six members of the vanilloid-like TRP-channel family which is now known as TRPV family.

Specifications

• Antigen: TRPV2 (extracellular)
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Trpv2
• Gene Alias: Grc; Growth factor-regulated calcium channel; Osm-9-like TRP channel 2; OTRPC2; RP23-234K24.7; Sac2b; Stretch-activated channel 2B; Transient receptor potential cation channel subfamily V member 2; Trpv2; Vanilloid receptor-like protein 1; VRL; Vrl1; VRL-1
• Host Species: Guinea Pig
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 29465
• Content And Storage: -20°C
• Form: Lyophilized

• Applications: Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunomicroscopy, Western Blot
• Concentration: 0.85 mg/mL
• Formulation: PBS with 1% BSA and 0.05% sodium azide; pH 7.4
• Gene Accession No.: Q9WUD2
• Gene Symbols: Trpv2
• Immunogen: Peptide corresponding to amino acid residues 413-428 of rat TRPV2 (1stextracellular loop)
• Quantity: 50 μL
• Primary or Secondary: Primary
• Target Species: Rat
• Product Type: Antibody
• Isotype: IgG