Invitrogen™ TRPM8 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA533090

Product Code. 13464759

Description

Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Baboon, Monkey, Marmoset, Bat, Dog, Hamster, Elephant, Panda, Rabbit, Opossum, Guinea pig, Platypus (100%); Galago, Mouse, Rat, Horse, Pig, Armadillo (94%); Bovine, Lizard (88%); Xenopus (82%). Immunohistochemistry with formalin-fixed paraffin-embedded tissues requires pretreatment with Proteinase K.

TRPM8 is a receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. TRPM8 is activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH and involved in menthol sensation. TRPM8 is permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. TRPM8 has an expression pattern within normal human tissues that is mostly restricted to prostate epithelial cells. TRPM8 mRNA expression is at moderate levels in normal prostate tissue and appears to be elevated in prostate cancer. Notably, TRPM8 mRNA was also expressed in a number of nonprostatic primary tumors of breast, colon, lung, and skin origin, whereas transcripts encoding TRPM8 were hardly detected or not detected in the corresponding normal human tissues.

Specifications

• Antigen: TRPM8
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: TRPM8
• Gene Alias: CMR1; Cold menthol receptor 1; cold/menthol receptor 1; long transient receptor potential channel 6; LTRPC6; LTrpC-6; MGC2849; short form of the TRPM8 cationic channel; transient receptor melastatin 8 variant 1; transient receptor melastatin 8 variant 2; transient receptor potential cation channel subfamily M member 8; transient receptor potential cation channel, subfamily M, member 8; transient receptor potential p8; transient receptor potential subfamily M member 8; transient receptor potential-p8; TRP ion channel TRPM8; Trpm8; Trpp8; trp-p8
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 100337634, 100351107, 100754189, 486170, 79054
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 1 mg/mL
• Formulation: PBS with 0.1% sodium azide
• Gene Accession No.: Q7Z2W7
• Gene Symbols: TRPM8
• Immunogen: Synthetic 17 amino acid peptide from N-terminal cytoplasmic domain of human TRPM8.
• Quantity: 50 μg
• Primary or Secondary: Primary
• Target Species: Human, Canine, Rabbit, Monkey, Hamster, Guinea Pig, Bat
• Product Type: Antibody
• Isotype: IgG