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Trimetrexate, MedChemExpress

Product Code. 16476627
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Quantity:
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10 mg
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Product Code. 16476627

Brand: Medchem Express HY10373

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Description

MedChemExpress Trimetrexate (CI-898) is an antibiotic, also a potent and orally active dihydrofolate reductase (DHFR) inhibitor, reducing the production of DNA and RNA precursors and leading to cell death, with IC50 values of 4.74 nM and 1.35 nM for human DHFR and Toxoplasma gondii DHFR. Trimetrexate can also inhibit the growth of various cancer cells. Trimetrexate can be used for researching Pneumocystis carinii pneumonia (PCP) and cancer.

Trimetrexate (CI-898) is an antibiotic, also a potent and orally active dihydrofolate reductase (DHFR) inhibitor, reducing the production of DNA and RNA precursors and leading to cell death, with IC50 values of 4.74 nM and 1.35 nM for human DHFR and Toxoplasma gondii DHFR. Trimetrexate can also inhibit the growth of various cancer cells. Trimetrexate can be used for researching Pneumocystis carinii pneumonia (PCP) and cancer.

Specifications

Chemical Name or Material Trimetrexate
Physical Form Solid
CAS 52128-35-5
Color Yellow
Quantity 5 mg
Purity Grade Notes Research
Molecular Formula C19H23N5O3
For Use With (Application) COVID-19-immunoregulation
Synonym CI-898
Solubility Information DMSO : ≥ 61.5 mg/mL (166.48 mM)
SMILES NC1=C(C(C)=C2CNC3=CC(OC)=C(OC)C(OC)=C3)C(C=C2)=NC(N)=N1
Molecular Weight (g/mol) 369.42
Formula Weight 369.42
Percent Purity 99.22%
Grade Research
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Research purposes only

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