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Trimethyl orthoformate, 99%

Product Code. 11464804
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Regulatory: This product is an isolated intermediate transported in accordance with Regulation (EC) 1907/2006 (REACH). All customers must complete a declaration before delivery.
Product Code. 11464804 Supplier Thermo Scientific Alfa Aesar Supplier No. A13760.0F
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Estimated Shipment: 19-11-2026
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Normativa: Este producto es un intermedio aislado transportado de acuerdo con el Reglamento (CE) 1907/2006 (REACH). Todos los clientes deben completar una declaración antes de la entrega.

CAS: 149-73-5 | C4H10O3 | 106.121 g/mol

Trimethyl orthoformate is used as a protecting group for aldehydes in organic synthesis, as an additive in polyurethane coatings and as a dehydrating agent in the preparation of surface modified colloidal silica nanoparticles. It is also used as a chemical intermediate in the preparation of vitamin B1 and sulfa drugs. It acts as an effective solvent for thallium(III) nitrate-mediated oxidations. Furthermore. It is utilized for the synthesis of chromone from keto-hydroxy naphthol in the presence of trimethylamine.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Trimethyl orthoformate is used as a protecting group for aldehydes in organic synthesis, as an additive in polyurethane coatings and as a dehydrating agent in the preparation of surface modified colloidal silica nanoparticles. It is also used as a chemical intermediate in the preparation of vitamin B1 and sulfa drugs. It acts as an effective solvent for thallium(III) nitrate-mediated oxidations. Furthermore. It is utilized for the synthesis of chromone from keto-hydroxy naphthol in the presence of trimethylamine.

Solubility
Miscible with ether, alcohol and benzene.

Notes
Moisture sensitive. Keep the container tightly closed in a dry and well-ventilated place. Incompatible with acids and strong oxidizing agents.
TRUSTED_SUSTAINABILITY

Identificadores de productos químicos

CAS 149-73-5
Molecular Formula C4H10O3
Molecular Weight (g/mol) 106.121
MDL Number MFCD00008483
InChI Key PYOKUURKVVELLB-UHFFFAOYSA-N
Synonym trimethyl orthoformate, methyl orthoformate, methane, trimethoxy, orthoformic acid, trimethyl ester, orthoformic acid methyl ester, orthomravencan methylnaty, methoxymethylal, methylester kyseliny orthomravenci, unii-xam28819yj, orthoformic acid trimethyl ester
PubChem CID 9005
IUPAC Name trimethoxymethane
SMILES COC(OC)OC

Especificaciones

Melting Point -53°C
Density 0.968
Boiling Point 101°C to 102°C
Flash Point 15°C (59°F)
Refractive Index 1.379
Quantity 2500 mL
UN Number UN3272
Beilstein 969215
Sensitivity Moisture sensitive
Merck Index 14,6884
Solubility Information Miscible with ether,alcohol and benzene.
Formula Weight 106.12
Percent Purity 99%
Chemical Name or Material Trimethyl orthoformate
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Nombre del producto
  • Trimethyl orthoformate
Palabra de advertencia
  • Danger
Clasificación
  • Serious eye damage/eye irritation Category 2
  • Flammable liquid Category 2
Indicaciones de peligro
  • H225-Highly flammable liquid and vapour.
  • H319-Causes serious eye irritation.
Consejos de prudencia
  • P210-Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.
  • P240-Ground/bond container and receiving equipment.
  • P280-Wear protective gloves/protective clothing/eye protection/face protection.
  • P305+P351+P338-IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
Otros peligros
  • MIXTURE LIST-Contain: Methyl orthoformate

RUO – Research Use Only

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