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Invitrogen™ TRIM5 gamma Polyclonal Antibody

Product Code. 12838262
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Quantity:
100 μg
Unit Size:
100µg
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12838262 100 μg 100µg
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Product Code. 12838262 Supplier Invitrogen™ Supplier No. PA520047

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Description

Rabbit Polyclonal Antibody

In Western blot applications, this antibody detects a band at ~35kDa. A suggested positive control is human bladder tissue lysate. PA5-20047 can be used with blocking peptide PEP-0166.

TRIM5 is a member of a broad family of otherwise unrelated proteins defined by the presence of a tripartite motif containing a RING domain, a B-box type 1, and a B-box type 2, followed by a coiled-coil region. TRIM5 has five alternately spliced isoforms, the longest of which is the alpha variant which also contains a carboxy-terminal B30.2 (SPRY) domain. While a function has not yet been assigned to TRIM5-gamma, it is known that expression of TRIM5-a variants from humans, rhesus monkeys, and African green monkeys enable resistance to infection by various retroviruses including HIV-1, albeit at differing efficiencies. Furthermore, the TRIM5δ isoform appears to serve as a scaffold for the assembly of endogenous BTBD1 and BTBD2 proteins and also exhibits autoubiquitination activity in a RING finger- and UbcH5B-dependent manner.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TRIM5 gamma
Applications Immunohistochemistry, Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene TRIM5
Gene Accession No. Q9C035
Gene Alias RING finger protein 88; RING-type E3 ubiquitin transferase TRIM5; RNF88; TRIM5; TRIM5alpha; tripartite motif containing 5; tripartite motif containing 5 transcript variant iota; tripartite motif containing 5 transcript variant kappa; tripartite motif protein TRIM5; tripartite motif-containing protein 5
Gene Symbols TRIM5
Host Species Rabbit
Immunogen A synthetic peptide corresponding to 15 amino acids near the carboxy terminus of human TRIM5 gamma.
Purification Method Antigen Affinity Chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 85363
Target Species Human
Content And Storage Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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