Invitrogen™ TRIF Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA588150

Product Code. 16576461

Description

Positive Samples: A-549, U-251MG, 22RV1, Mouse spleen, Mouse eye, Rat spleen; Cellular Location: Cytoplasmic vesicle, autophagosome Immunogen sequence: RPIDGVSDWS QGCSLRSTGS PASLASNLEI SQSPTMPFLS LHRSPHGPSK LCDDPQASLV PEPVPGGCQE PEEMSWPPSG EIASPPELPS SPPPGLPEVA P.

Involved in innate immunity against invading pathogens. Adapter used by TLR3 and TLR4 (through TICAM2) to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TRIF recruitment through its TIR domain. Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively.

Specifications

• Antigen: TRIF
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: TICAM1
• Gene Alias: AW046014; AW547018; hCG_39321; HSD34; IIAE6; MyD88-3; Proline-rich, vinculin and TIR domain-containing protein B; PRVTIRB; Putative NF-kappa-B-activating protein 502H; RNF36; TI; Ticam1; TICAM-1; TIR domain containing adaptor inducing interferon-beta; TIR domain-containing adapter molecule 1; TIR domain-containing adapter protein inducing IFN-beta; TIR domain-containing adaptor inducing interferon-beta; TIR-domain containing adaptor inducing interferon-beta; toll like receptor adaptor molecule 1; toll-interleukin 1 receptor domain-containing adapter protein inducing interferon-beta; toll-interleukin I receptor domain containing adaptor molecule 1; toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta; toll-like receptor adaptor molecule 1; TRIF
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 106759, 148022, 363328
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot, Immunocytochemistry
• Concentration: 0.79 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: Q80UF7, Q8IUC6
• Gene Symbols: TICAM1
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 180-280 of human TRIF / TICAM1 (NP_8915491).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG