Tocris Bioscience™ Trichostatin A

Product Code. 18722564

Brand: Tocris Bioscience™ 1406/1

Description

Potent histone deacetylase inhibitor

Trichostatin A is a selective and potent inhibitor of class I and II histone deacetylases (HDAC) (Ki = 3.4 nM, IC50 values are 4.99 nM, 5.21 nM, 16.4 nM, 24.3 nM, 27.6 nM for HDAC1, 3, 6, 10 and 4, respectively). Trichostatin A induces accelerated dedifferentiation of primordial germ cells (PGCs) into embryonic germ (EG) cells. Trichostatin A potently inhibits a range of breast cancer and melanoma cell lines (IC50 = 29-400 nM) and induces apoptosis in prostate cancer cells. In an animal model of Huntington's disease, inhibition of HDAC by Trichostatin A rescues memory deficits and increases expression of CREB/CBP target genes in mutant mice. Activates autophagy, increases vesicular transport of BDNF (Cat. No. 2837) and is active in vivo.

Specifications

• CAS: 58880-19-6
• Quantity: 1 mg
• Molecular Formula: C17H22N2O3
• Formula Weight: 302.37
• Purity: 97%
• Molecular Weight (g/mol): 302.37
• Chemical Name or Material: Trichostatin A