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Invitrogen™ TRIB1 Polyclonal Antibody
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Product Code. 15694775
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Quantity:
100 μL
Unit Size:
100µL
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15694775 100 μL 100µL
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Product Code. 15694775 Supplier Invitrogen™ Supplier No. PA550851

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Description

Rabbit Polyclonal Antibody

The antibody detects endogenous levels of total TRIB1 protein.

TRIB1 also called gprotein coupled receptor induced, skip1, gig2, c8fwATP, functions in binding protein binding, protein kinase inhibitor activity, and protein serine/threonine kinase activities. Overexpression of TRIB1 in HeLa cells repressed the basal activity of the IL8 promoter by inhibiting AP1 activity. Overexpression of TRIB1 inhibited oncogenic Ras -driven AP1 activation and MEKK1-mediated AP1 activation. ERK activation was enhanced by TRIB1. Coimmunoprecipitation and yeast 2-hybrid assays showed that MEK1 interacted with both TRIB1 and TRIB3, and MKK4 interacted specifically with TRIB1. Cotransfection of MKK4 enhanced the level of TRIB1, indicating that the TRIB-MAPKK interaction stabilized TRIB1.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TRIB1
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 1.4 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.05% sodium azide; pH 7.4
Gene TRIB1
Gene Accession No. Q8K4K4, Q96RU8
Gene Alias A530090O15Rik; C8FW; Gig2; GIG-2; G-protein-coupled receptor induced protein; G-protein-coupled receptor induced protein GIG2; G-protein-coupled receptor-induced gene 2 protein; G-protein-coupled receptor-induced protein 2; phosphoprotein regulated by mitogenic pathways; SKIP1; Trb1; TRB-1; Trib1; tribbles homolog 1; tribbles homolog 1 (Drosophila); tribbles pseudokinase 1; tribbles-like protein 1
Gene Symbols TRIB1
Host Species Rabbit
Immunogen Synthetic peptide corresponding to residues near the C terminal of human tribbles pseudokinase 1.
Purification Method Antigen Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 10221, 211770
Target Species Human, Mouse
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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