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Invitrogen™ TREX2 Polyclonal Antibody

Product Code. 12858812
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Quantity:
100 μg
Unit Size:
100µg
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12858812 100 μg 100µg
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Product Code. 12858812 Supplier Invitrogen™ Supplier No. PA520666

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Description

Rabbit Polyclonal Antibody

A suggested positive control is rat liver tissue lysate. PA5-20666 can be used with blocking peptide PEP-0786. Antibodies should not be exposed to prolonged high temperatures.

TREX2 is one of two major human 3' to 5' exonucleases which are required for checkpoint signaling after DNA damage. While the related protein TREX1 is required for ATR expression and mutations in this gene result in Aicardi-Goutieres syndrome, chilblain lupus, and Cree encephalitis, less is known about TREX2. Like TREX1, TREX2 is ubiquitously expressed in all tissues examined. X-ray crystallography studies of TREX2-single strand DNA complexes revealed that TREX2 binds DNA as a dimer and may act to displace the second DNA strand, suggesting that TREX2 unzips and denatures double stranded DNA and feed the substrate DNA strand into the TREX2 active site. At least two isoforms of TREX2 are known to exist.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TREX2
Applications Immunohistochemistry, Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene TREX2
Gene Accession No. Q9BQ50, Q9R1A9
Gene Alias 3'-5' exonuclease TREX2; 3'-5' exonuclease TREX2 long form; RGD1562245; Three prime repair exonuclease 2; Trex2
Gene Symbols TREX2
Host Species Rabbit
Immunogen A 15 amino acid peptide near the carboxy terminus of human TREX2.
Purification Method Antigen Affinity Chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 11219, 24102, 309275
Target Species Human, Mouse, Rat
Content And Storage 4°C
Product Type Antibody
Form Liquid
Isotype IgG
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