Invitrogen™ TREX1 Recombinant Rabbit Monoclonal Antibody (24GB2440)

Rabbit Recombinant Monoclonal Antibody

Product Code	Brand	Quantity
30276444	Invitrogen™ MA557774	100 μL
30276484	Invitrogen™ MA557775	20 μL

Description

TREX1 Recombinant Monoclonal Antibody for Western Blot, ICC/IF, Flow

Trex1 (ATRIP) is the major human 3' to 5' exonuclease which is required for checkpoint signaling after DNA damage. It is ubiquitously expressed, binds to single stranded DNA coated with replication protein A that accumulates at sites of DNA damage and recruits the ataxia telangiectasia and Rad3 related protein (ATR), a checkpoint kinase, to sites of DNA damage and replication stress. Trex1 is required for ATR expression. This gene uses two different open reading frames. The upstream ORF encodes proteins which interact with ATR and localize to intranuclear foci induced by DNA damage and are essential components of the DNA damage checkpoint. The downstream ORF encodes proteins with 3' to 5' exonuclease activity and may be a subunit of human DNA polymerase III. Multiple transcript variants encoding different isoforms have been found. Mutations in this gene result in Aicardi-Goutieres syndrome, chilblain lupus, and Cree encephalitis.

Specifications

• Antigen: TREX1
• Concentration: 1.5 mg/mL
• Applications: Flow Cytometry, Western Blot, Immunocytochemistry
• Conjugate: Unconjugated
• Host Species: Rabbit
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: Q9NSU2
• Gene ID (Entrez): 11277
• Immunogen: A synthesized peptide derived from human TREX1 (aa 150-314).
• Product Type: Antibody

• Clone: 24GB2440
• Content And Storage: -20°C
• Classification: Recombinant Monoclonal
• Form: Liquid
• Isotype: IgG
• Target Species: Human
• Gene: TREX1
• Gene Alias: 1661; 3' repair exonuclease 1; 3'-5' exonuclease TREX1; AGS1; AU041952; CRV; Deoxyribonuclease III; DNase III; DRN3; HERNS; RGD1309596; three prime exonuclease 1; three prime repair exonuclease 1; three-prime repair exonuclease 1; Trex1; trophoblast expressed 1
• Gene Symbols: TREX1
• Primary or Secondary: Primary
• Purification Method: Affinity chromatography