Invitrogen™ Transferrin Receptor Monoclonal Antibody (H68.4)

Product Code.	Quantity	unitSize
10372703	100 μg	Each
10516083	500 μg	Each

Product Code. 10372703

Brand: Invitrogen™ 136800

Description

Mouse Monoclonal Antibody

H68.4 is specific to residues 3-28 of the human transferrin receptor (TfR) tail.

Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system. Serum transferrin receptor (sTfR) is used as a means of detecting erythropoietin (EPO) misuse by athletes and as a diagnostic test for anemias resulting from a number of conditions including rheumatoid arthritis, pregnancy, irritable bowel syndrome and in HIV patients.

Specifications

• Antigen: Transferrin Receptor
• Applications: ELISA, Immunohistochemistry (Paraffin), Immunomicroscopy, Immunoprecipitation, Western Blot, Immunocytochemistry
• Classification: Monoclonal
• Clone: H68.4
• Concentration: 0.5 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 0.1% sodium azide; pH 7.4
• Gene: TFRC
• Gene Accession No.: P02786, Q07891, Q62351, Q90997, Q99376
• Gene Alias: 2610028K12Rik; AI195355; AI426448; AU015758; CD antigen CD71; CD71; chicken transferrin receptor; E430033M20Rik; I79_000642; IMD46; mammary tumor virus receptor 1; Mtvr1; Mtvr-1; p90; sTfR; T9; TfR; tfR1; TFR2; TFRC; TR; transferrin receptor; transferrin receptor (p90, CD71); transferrin receptor 2; transferrin receptor protein 1; Transferrin receptor protein 1, serum form; Trfr
• Gene Symbols: TFRC
• Host Species: Mouse
• Immunogen: Recombinant human transferrin receptor.
• Purification Method: Affinity chromatography
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 100689395, 22042, 396191, 64678, 7037
• Target Species: Human, Mouse, Rat, Hamster, Chicken
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG1