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Invitrogen™ TRAF7 Polyclonal Antibody
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Product Code. 16629154
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Quantity:
100 μL
Unit Size:
100µL
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16629154 100 μL 100µL
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Product Code. 16629154 Supplier Invitrogen™ Supplier No. PA5102692

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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total TRAF7.

TRAFs are signal transducers for members of TNFR superfamily. These are critically involved in activation of MAP3K family members involved in NF-kappaB and JNK activation and apoptosis. TRAF7, a novel 670 A. A protein, is a human homolog of mouse Traf7 andconsists of an N-terminal RING finger domain, central TRAF domain, a coiled-coil motif and 7 WD40 repeats at the C-terminus. It has E3-ubiquitin ligase activity for self-ubiquitination. TRAF7 specifically interacts with MEKK3 and mediates MEKK3-induced AP1 and CHOP activation and induces apoptosis through Caspase-independent pathways. It is a multifunctional protein involved in sumoylation and negative regulation of c-Myb, thereby regulating proliferation and differentiation of hematopoietic cells.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TRAF7
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene TRAF7
Gene Accession No. Q6Q0C0, Q922B6
Gene Alias DKFZp586I021; E3 ubiquitin-protein ligase TRAF7; MGC7807; RFWD1; RGD1559653; ring finger and WD repeat domain 1; ring finger and WD repeat domain 1 isoform 1; RING finger and WD repeat-containing protein 1; RING finger protein 119; RING-type E3 ubiquitin transferase TRAF7; RNF119; TNF receptor associated factor 7; TNF receptor-associated factor 7; TNF receptor-associated factor 7, E3 ubiquitin protein ligase; traf7
Gene Symbols TRAF7
Host Species Rabbit
Immunogen A synthesized peptide derived from human TRAF7(Accession Q6Q0C0), corresponding to amino acid residues A37-D87.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 224619, 360491, 84231
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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