Invitrogen™ TRAF7 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA5102692

Product Code. 16629154

Description

Antibody detects endogenous levels of total TRAF7.

TRAFs are signal transducers for members of TNFR superfamily. These are critically involved in activation of MAP3K family members involved in NF-kappaB and JNK activation and apoptosis. TRAF7, a novel 670 A. A protein, is a human homolog of mouse Traf7 andconsists of an N-terminal RING finger domain, central TRAF domain, a coiled-coil motif and 7 WD40 repeats at the C-terminus. It has E3-ubiquitin ligase activity for self-ubiquitination. TRAF7 specifically interacts with MEKK3 and mediates MEKK3-induced AP1 and CHOP activation and induces apoptosis through Caspase-independent pathways. It is a multifunctional protein involved in sumoylation and negative regulation of c-Myb, thereby regulating proliferation and differentiation of hematopoietic cells.

Specifications

• Antigen: TRAF7
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: TRAF7
• Gene Alias: DKFZp586I021; E3 ubiquitin-protein ligase TRAF7; MGC7807; RFWD1; RGD1559653; ring finger and WD repeat domain 1; ring finger and WD repeat domain 1 isoform 1; RING finger and WD repeat-containing protein 1; RING finger protein 119; RING-type E3 ubiquitin transferase TRAF7; RNF119; TNF receptor associated factor 7; TNF receptor-associated factor 7; TNF receptor-associated factor 7, E3 ubiquitin protein ligase; traf7
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 224619, 360491, 84231
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: Q6Q0C0, Q922B6
• Gene Symbols: TRAF7
• Immunogen: A synthesized peptide derived from human TRAF7(Accession Q6Q0C0), corresponding to amino acid residues A37-D87.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG