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Description
Tumor necrosis factor receptor (TNFR) superfamily members transmit signals regulating proliferation, differentiation and apoptosis in various types of cells. TNFR-associated factors (TRAFs) are a family of proteins that were initially discovered as downstream signal transducers of the TNFR superfamily. TRAF3 contains an N-terminal ring finger/zinc finger region that is thought to be essential for downstream signaling. MIP-T3 is associated with TRAF3. MIP-T3 binds to taxol-stabilized microtubules and to tubulin in vitro, and MIP-T3 recruits TRAF3 to microtubules when both proteins are overexpressed. The MIP-T3/TRAF3 interaction requires the coiled-coil TRAF-N domain of TRAF3. This interaction may provide a novel mechanism in sequestering TRAF3 to the cytoskeletal network.
Specifications
Specifications
| Antigen | TRAF3IP1 |
| Applications | Immunohistochemistry (Paraffin), Immunofluorescence, Immunoprecipitation, Immunocytochemistry, Western Blot |
| Classification | Polyclonal |
| Concentration | 0.24 mg/mL |
| Conjugate | Unconjugated |
| Formulation | PBS with 50% glycerol and 0.1% sodium azide; pH 7.3 |
| Gene | TRAF3IP1 |
| Gene Accession No. | Q149C2, Q5XIN3, Q8TDR0 |
| Gene Alias | MIP T3, MIPT3, TRAF3 interacting protein 1, TRAF3IP1 |
| Gene Symbols | Traf3ip1 |
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Product Title
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