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Invitrogen™ TRAF2 Polyclonal Antibody

Product Code. 12818232
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Quantity:
100 μg
Unit Size:
100µg
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12818232 100 μg 100µg
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Product Code. 12818232 Supplier Invitrogen™ Supplier No. PA520193

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Beskrivning

Rabbit Polyclonal Antibody

A suggested positive control is human liver tissue lysate. PA5-20193 can be used with blocking peptide PEP-0323.

Tumor necrosis factor (TNF) receptor associated factors (TRAFs) were initially discovered as adaptor proteins that link the TNF receptor superfamily to signaling pathways and are thus important regulators of cell death and cellular response to stress. TRAF proteins share a homology region that allows them to bind to cell receptors and other TRAF proteins, causing the activation of different signal cascades depending on the TRAFs involved. For example, TRAF2 and TRAF3 directly bind to the CD40, a NF receptor superfamily member involved in inducing B cell immunity, and are critical for NF-kappa-B activation in mouse B lymphocytes. TRAF2 along with TRAF6 has also been shown to be required for CD40 signaling in nonhemopoietic cells. TRAF2 also interacts with the TRFR superfamily member lymphotoxin-beta receptor (LTbetaR) in association with TRAF3 and the apoptosis inhibitors cIAP1 and Smac.
TRUSTED_SUSTAINABILITY

Specifikationer

Antigen TRAF2
Applications Immunohistochemistry, Immunoprecipitation, Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene TRAF2
Gene Accession No. P39429, Q12933
Gene Alias AI325259; E3 ubiquitin-protein ligase TRAF2; MGC:45012; OTTHUMP00000064745; RING-type E3 ubiquitin transferase TRAF2; TNF receptor associated factor 2; Tnf receptor-associated factor 2; TRAF2; TRAP; TRAP3; tumor necrosis factor type 2 receptor associated protein 3; tumor necrosis factor type 2 receptor-associated protein 3
Gene Symbols TRAF2
Host Species Rabbit
Immunogen A 16 amino acid peptide from near the amino terminus of human TRAF2.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 22030, 311786, 7186
Target Species Human, Mouse, Rat
Content And Storage Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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