Invitrogen™ TRADD Recombinant Rabbit Monoclonal Antibody (24GB2230)

Rabbit Recombinant Monoclonal Antibody

Brand:  Invitrogen™ MA557287

Product Code. 30276173

Description

TRADD Recombinant Monoclonal Antibody for Western Blot, ICC/IF, Flow

TRADD (Tumor necrosis factor receptor type 1-associated DEATH domain protein) is an important mediator of FAS and TNFR1 associated apoptotic signaling. The nuclear form acts as a tumor suppressor by preventing ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A by TRIP12. TRADD acts by interacting with TRIP12 and leading to the disruption of the interaction between TRIP12 and isoform p19ARF/ARF of CDKN2A. TRADD acts as an adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interation with FADD. Overexpression of TRADD leads to two major TNF-induced responses - apoptosis and activation of NF-kappa-B.

Specifications

• Antigen: TRADD
• Classification: Recombinant Monoclonal
• Concentration: 0.8 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: Q15628, Q3U0V2
• Gene Symbols: TRADD
• Immunogen: A synthesized peptide derived from human TRADD (aa 210-312).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

• Applications: Flow Cytometry, Western Blot, Immunocytochemistry
• Clone: 24GB2230
• Conjugate: Unconjugated
• Gene: TRADD
• Gene Alias: 9130005N23Rik; AA930854; Hs.89862; Hs89862; MGC11078; TNF receptor 1 associated signal transducer; TNFR1-associated DEATH domain protein; TNFRSF1A associated via death domain; TNFRSF1A-associated via death domain; TRADD; tumor necrosis factor receptor type 1 associated death domain protein; tumor necrosis factor receptor type 1-associated DEATH domain protein; tumor necrosis factor receptor-1-associated protein
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 246756, 71609, 8717
• Content And Storage: -20°C
• Form: Liquid