Invitrogen™ TPPP Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA531492

Product Code. 13446017

Description

Recommended positive controls: mouse brain, PC-12, Rat2, rat brain. Predicted reactivity: Mouse (94%), Rat (94%), Pig (96%), Rhesus Monkey (100%), Bovine (93%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Tubulin family members are globular proteins important in the assembly of microtubules. Microtubules are structural components that play important roles in mitosis, cytokinesis and vesicle transport. TPPP (Tubulin polymerization-promoting protein), also known as p24 and p25, is a widely expressed 219 amino acid protein found in the perinuclear region of the cytoplasm. TPPP may form dimers and functions in polymerizing tubulin into double-walled tubules, polymorphic aggregates, or stabilized blocks. TPPP overexpression prevents formation of the mitotic spindle assembly and breakdown of the nuclear envelope. TPPP is phosphorylated by TPK II and is encoded by a gene that maps to human chromosome 5, which contains 181 million base pairs and comprises nearly 6% of the human genome. May play a role in the polymerization of tubulin into microtubules, microtubule bundling and the stabilization of existing microtubules, thus maintaining the integrity of the microtubule network. May play a role in mitotic spindle assembly and nuclear envelope breakdown.

Specifications

• Antigen: TPPP
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: TPPP
• Gene Alias: 25 kDa brain-specific protein; 2900041A09Rik; AI849835; brain specific protein p25 alpha; brain-specific protein p25 alpha; glycogen synthase kinase 3 (GSK3) inhibitor p24; p24; p25; p25alpha; p25-alpha; RGD1310121; Tppp; TPPP/p25; TPPP1; tubulin polymerization promoting protein; tubulin polymerization-promoting protein
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 11076, 361466, 72948
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot
• Concentration: 0.87 mg/mL
• Formulation: PBS with 1% BSA, 20% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: O94811, Q7TQD2
• Gene Symbols: TPPP
• Immunogen: Recombinant protein encompassing a sequence within the center region of human TPPP. The exact sequence is proprietary.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG