Invitrogen™ TPM3 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ 720306

Product Code. 15934074

Description

These Polyclonal antibodies are of rabbit origin developed by immunizing animals with proteins or peptides. The polyclonal antibody is purified by affinity purification from the rabbit sera generated after immunizing the rabbits with a specific type of protein or peptide. The purified antibody is tested for its functionality in various relevant research applications. The antibody is developed for Research Use Only and is non-hazardous or non-infectious in nature. This antibody is predicted to react with Monkey, Horse, Rat and Pig.

TPM3 (tropomyosin 3) is a member of the tropomyosin family of actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosins are dimers of coiled-coil proteins that polymerize end-to-end along the major groove in most actin filaments. They provide stability to the filaments and regulate access of other actin-binding proteins. In muscle cells, they regulate muscle contraction by controlling the binding of myosin heads to the actin filament. Mutations in this gene result in autosomal dominant nemaline myopathy, and oncogenes formed by chromosomal translocations involving this locus are associated with cancer. Multiple transcript variants encoding different isoforms have been found for this gene.

Specifications

• Antigen: TPM3
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: TPM3
• Gene Alias: alpha-tropomyosin, slow skeletal; CAPM1; CFTD; cytoskeletal tropomyosin TM30; epididymis luminal protein 189; epididymis secretory sperm binding protein Li 82p; gamma-TM; gamma-tropomyosin; heat-stable cytoskeletal protein 30 kDa; HEL-189; HEL-S-82p; hscp30; hTM30nm; hTM5; hTMnm; NEM1; nonmuscle tropomyosin 5; OK/SW-cl.5; skalphaTM.2; TM3; TM30; TM30nm; TM5; TM-5; Tm5NM; TMnm; TPM3; Tpm5; Tpm-5; TPMsk3; TRK; Trop-5; tropomyosin; tropomyosin 3; tropomyosin 3, gamma; tropomyosin 5; tropomyosin alpha-3 chain; tropomyosin gamma; tropomyosin non-muscle; tropomyosin-3; Tropomyosin-5
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 117557, 59069, 7170
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot, Immunocytochemistry
• Concentration: 0.5 mg/mL
• Formulation: PBS with 0.1% BSA, 30% glycerol and 0.09% sodium azide; pH 7.4
• Gene Accession No.: P06753, P21107, Q63610
• Gene Symbols: TPM3
• Immunogen: Peptides corresponding to Human TPM3 (aa 40-49, 225-234).
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG