Invitrogen™ TPM3 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA529770

Product Code. 13494037

Description

Recommended positive controls: 293T. Predicted reactivity: Mouse (100%), Rat (100%), Zebrafish (80%), Dog (89%), Pig (100%), Rhesus Monkey (89%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

TPM3 (tropomyosin 3) is a member of the tropomyosin family of actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosins are dimers of coiled-coil proteins that polymerize end-to-end along the major groove in most actin filaments. They provide stability to the filaments and regulate access of other actin-binding proteins. In muscle cells, they regulate muscle contraction by controlling the binding of myosin heads to the actin filament. Mutations in this gene result in autosomal dominant nemaline myopathy, and oncogenes formed by chromosomal translocations involving this locus are associated with cancer. Multiple transcript variants encoding different isoforms have been found for this gene.

Specifications

• Antigen: TPM3
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: TPM3
• Gene Alias: alpha-tropomyosin, slow skeletal; CAPM1; CFTD; cytoskeletal tropomyosin TM30; epididymis luminal protein 189; epididymis secretory sperm binding protein Li 82p; gamma-TM; gamma-tropomyosin; heat-stable cytoskeletal protein 30 kDa; HEL-189; HEL-S-82p; hscp30; hTM30nm; hTM5; hTMnm; NEM1; nonmuscle tropomyosin 5; OK/SW-cl.5; skalphaTM.2; TM3; TM30; TM30nm; TM5; TM-5; Tm5NM; TMnm; TPM3; Tpm5; Tpm-5; TPMsk3; TRK; Trop-5; tropomyosin; tropomyosin 3; tropomyosin 3, gamma; tropomyosin 5; tropomyosin alpha-3 chain; tropomyosin gamma; tropomyosin non-muscle; tropomyosin-3; Tropomyosin-5
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 59069, 7170
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
• Concentration: 0.44 mg/mL
• Formulation: 0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: P06753, P21107
• Gene Symbols: TPM3
• Immunogen: Recombinant protein encompassing a sequence within the center region of human Tropomyosin 3. The exact sequence is proprietary.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG