TOX3 Antibody (TOX3/1124), DyLight 594, Novus Biologicals™

Mouse Monoclonal Antibody

Brand:  Novus Biologicals NBP2-47749DL594

Product Code. 18161988

Description

TOX3 Monoclonal specifically detects TOX3 in Human samples. It is validated for ELISA.

Specifications

• Antigen: TOX3
• Classification: Monoclonal
• Conjugate: DyLight 594
• Formulation: 50mM Sodium Borate with 0.05% Sodium Azide
• Gene Symbols: TOX3
• Immunogen: Recombinant fragment of human TOX3 protein (around aa 251-389) (Exact sequence is proprietary) (Uniprot: O15405)
• Quantity: 0.1 mL
• Primary or Secondary: Primary
• Target Species: Human
• Isotype: IgG1 κ

• Applications: Western Blot, Flow Cytometry, Immunofluorescence
• Clone: TOX3/1124
• Dilution: Western Blot, Flow Cytometry, Immunofluorescence
• Gene Alias: CAG trinucleotide repeat-containing gene F9 protein, CAGF9trinucleotide repeat containing 9, TNRC9, TOX high mobility group box family member 3, Trinucleotide repeat-containing gene 9 protein
• Host Species: Mouse
• Purification Method: Protein A or G purified
• Regulatory Status: RUO
• Test Specificity: It recognizes a 63kDa protein, which is identified as TOX3. It contains a high mobility group (HMG)-box, which regulates Ca2+-dependent transcription in neurons through interaction with the cAMP-response-element-binding protein (CREB). TOX3 appears to be associated with breast cancer susceptibility and is expressed downstream of a cytoprotective cascade together with CITED1, a transcriptional regulator that does not bind directly to DNA. TOX3 is predominantly expressed in the brain and forms homodimers. TOX3 overexpression protects neuronal cells from cell death caused by endoplasmic reticulum stress or BAX overexpression through the induction of anti-apoptotic transcripts and repression of pro-apoptotic transcripts.
• Content And Storage: Store at 4°C in the dark.