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STEMCELL Technologies Torin 1

Product Code. 17150232
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Quantity:
10 mg
50 mg
Unit Size:
10mg
50mg
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Product Code. 17150232

Brand: STEMCELL Technologies 73492

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This item is not returnable. View return policy

Description

mTOR pathway inhibitor; Inhibits mTORC1 and mTORC2 complexes

  • Torin 1 is an ATP-competitive inhibitor of the mammalian target of rapamycin (mTOR), inhibiting the mTOR complexes mTORC1 and mTORC2 with IC50 values of 2 and 10 nM respectively
  • It is selective for mTOR versus a panel of over 400 other kinases screened at 10 μM (Thoreen et al.; Liu et al.)
  • Inhibits tumor growth, likely through a cytostatic rather than cytotoxic mechanism, in a U87MG PTEN-null glioblastoma mouse xenograft model (Liu et al.)
  • Hinders growth, motility, invasion, and survival of primary colon cancer stem-like cells in vitro, and suppresses tumor growth but does not affect normal colon stem cells in xenografts (Francipane & Lagasse)

Specifications

CAS 1222998-36-8
Quantity 10 mg
Molecular Formula C35H28F3N5O2
Purity ≥95%
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