missing translation for 'onlineSavingsMsg'
Learn More
  1. Home
  2. Products
  3. Chemicals
  4. Organic compounds
  5. Organoheterocyclic compounds
  6. Pyranopyridines
  7. Topotecan hydrochloride, Tocris Bioscience™

Topotecan hydrochloride, Tocris Bioscience™

Product Code. 18772544
Change view
Click to view available options
Quantity:
10 mg
50 mg
Unit Size:
10mg
50mg
Product Code. Quantity unitSize
18772544 10 mg 10mg
18742584 50 mg 50mg
2 options
This item is not returnable. View return policy

Product Code. 18772544

Brand: Tocris Bioscience 4562/10

Please to purchase this item. Need a web account? Register with us today!

This item is currently unavailable or has been discontinued.
View the product page for possible alternatives.
 View alternative products

This item is not returnable. View return policy

Description

DNA topoisomerase I inhibitor; Camptothecin (Cat. No. 1100) analog

Topotecan hydrochloride is a DNA topoisomerase I inhibitor; induces rapid apoptotic death in human B-lineage acute lymphoblastic leukemia (ALL) cells. Improves survival in three mouse models of poor prognosis ALL; downregulates B-Myb and MycN expression in neuroblastoma cells. Water-soluble analog of Camptothecin (Cat. No. 1100). Orally bioavailable. Topotecan disrupts the interaction between NHP2L1 and U4 RNA by binding to U4 and inhibits RNA splicing.
TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 119413-54-6
Molecular Formula C23H23N3O5
Molecular Weight (g/mol) 421.45
MDL Number MFCD28989044
InChI Key UCFGDBYHRUNTLO-QHCPKHFHSA-N
Synonym topotecan hydrochloride, topotecan hcl, hycamptamine hydrochloride, topotecan monohydrochloride, unii-956s425zcy, topotecan hydrochloride usan, nogitecan hydrochloride, dsstox_cid_25952, dsstox_rid_81248
PubChem CID 60699
IUPAC Name (19S)-8-[(dimethylamino)methyl]-19-ethyl-7,19-dihydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.0²,¹¹.0⁴,⁹.0¹⁵,²⁰]henicosa-1(21),2,4,6,8,10,15(20)-heptaene-14,18-dione
SMILES CC[C@@]1(O)C(=O)OCC2=C1C=C1N(CC3=CC4=C(CN(C)C)C(O)=CC=C4N=C13)C2=O

Specifications

Quantity 10 mg
Formula Weight 457.91
Percent Purity >98%
Chemical Name or Material Topotecan hydrochloride
Product Title
Select an issue

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.