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Invitrogen™ TOLLIP Polyclonal Antibody

Product Code. 12818242
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Quantity:
100 μg
Unit Size:
100µg
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12818242 100 μg 100µg
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Product Code. 12818242 Supplier Invitrogen™ Supplier No. PA520204

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Description

Rabbit Polyclonal Antibody

A suggested positive control is rat brain tissue lysate. PA5-20204 can be used with blocking peptide PEP-0345.

Toll-like receptors (TLRs) are evolutionarily conserved pattern-recognition molecules resembling the toll proteins that mediate antimicrobial responses in Drosophila. These proteins recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. The TLRs act through adaptor molecules to activate various kinases and transcription factors so the organism can respond to potential infection. These adaptor molecules include TOLLIP, MyD88, and TRIF. TOLLIP associates directly with TLR2 and TLR 4, acting as an inhibitor to TLR activation. This negative regulation of TLR signaling may serve to limit the production of proinflammatory mediators during infection and inflammation.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TOLLIP
Applications Immunohistochemistry, Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene TOLLIP
Gene Accession No. A2RUW1, Q9H0E2, Q9QZ06
Gene Alias 4930403G24Rik; 4931428G15Rik; adapter protein; EMBL:AAI33068.1}; FLJ33531; IL-1RAcPIP; toll interacting protein; toll-interacting protein; TOLLIP; tollip {ECO:0000312
Gene Symbols TOLLIP
Host Species Rabbit
Immunogen A 16 amino acid peptide from near the carboxy terminus of human TOLLIP.
Purification Method Antigen Affinity Chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 361677, 54472, 54473
Target Species Human, Mouse, Rat
Content And Storage Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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