Tolfenamic acid, 99+%

Artikelnummer.	Quantity	Packungsgröße
15473869	10 g	10g
15463869	5 g	5g

Artikelnummer. 15473869 Lieferant Thermo Scientific Alfa Aesar Lieferanten-Nr. J61256.09

Beschreibung

NSAID that activates calcium-activated potassium channels | CAS: 13710-19-5 | C14H12ClNO2 | 261.705 g/mol

Tolfenamic acid is a non-steroidal anti-inflammatory agent. It interferes with synthesis of β-amyloid precursor protein, and thus Aβ peptides, by promoting degradation of an essential transcription factor. It inhibits fMLP- and A23187-induced Ca2+ influx in human PMNL with an IC50 value of approximately 20 μM.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Tolfenamic acid is a non-steroidal anti-inflammatory agent. It interferes with synthesis of β-amyloid precursor protein, and thus Aβ peptides, by promoting degradation of an essential transcription factor. It inhibits fMLP- and A23187-induced Ca2+ influx in human PMNL with an IC50 value of approximately 20 µM.

Solubility
Soluble in water (slightly), acetone (∼10 mg/ml), DMSO (52 mg/ml at 25°C), methanol (∼10 mg/ml) and ethanol (50 mg/ml).

Notes
Stable under recommended storage conditions. Incompatible with oxidizing agents.

Spezifikation

Chemische Identifikatoren

• CAS: 13710-19-5
• Molecular Formula: C14H12ClNO2
• Molecular Weight (g/mol): 261.705
• MDL Number: MFCD00133865
• InChI Key: YEZNLOUZAIOMLT-UHFFFAOYSA-N
• Synonym: tolfenamic acid, clotam, n-3-chloro-2-methylphenyl anthranilic acid, 2-3-chloro-2-methylphenyl amino benzoic acid, tolfedine, acido tolfenamico, acide tolfenamique, acidum tolfenamicum, tolfine, n-2-methyl-3-chlorophenyl anthranilic acid
• PubChem CID: 610479
• ChEBI: CHEBI:32243
• IUPAC Name: 2-(3-chloro-2-methylanilino)benzoic acid
• SMILES: CC1=C(C=CC=C1Cl)NC2=CC=CC=C2C(=O)O

• Color: White
• Quantity: 10 g
• UN Number: UN2811
• Merck Index: 14,9513
• Solubility Information: Soluble in water (slightly),acetone (∽10mg/ml),DMSO (52mg/ml at 25°C),methanol (∽10mg/ml) and ethanol (50mg/ml).
• Formula Weight: 261.7
• Percent Purity: ≥99%
• Physical Form: Crystalline Powder
• Chemical Name or Material: Tolfenamic acid

Sicherheit und Handhabung

Produktidentifikator

• Tolfenamic acid

Signalwort

• Danger

Gefahrenkategorie

• Acute toxicity Category 3

Gefahrenhinweis

• H301-Toxic if swallowed.

Sicherheitshinweis

• P264-Wash face, hands and anyexposed skin thoroughly after handling.
• P301+P310-IF SWALLOWED: Immediately call a POISON CENTER/doctor /

Ergänzende Informationen

• MIXTURE LIST-Contain: Tolfenamic acid

Sicherheitsdatenblatt (SDS)

RUO – Research Use Only