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Tolcapone, MedChemExpress

Product Code. 16487286
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Product Code. 16487286

Brand: Medchem Express HY17406

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Description

MedChemExpress Tolcapone (Ro 40-7592) is a selective, orally active and powerful mixed (peripheral and central) COMT inhibitor with an IC50 of 773 nM in the liver. Tolcapone is also a potent inhibitor of α-syn and Aβ42 oligomerization and fibrillogenesis. Tolcapone induces oxidative stress leading to apoptosis and inhibition of tumor growth in neuroblastoma.

Tolcapone (Ro 40-7592) is a selective, orally active and powerful mixed (peripheral and central) COMT inhibitor with an IC50 of 773 nM in the liver. Tolcapone is also a potent inhibitor of α-syn and Aβ42 oligomerization and fibrillogenesis. Tolcapone induces oxidative stress leading to apoptosis and inhibition of tumor growth in neuroblastoma.

Specifications

Chemical Name or Material Tolcapone
CAS 134308-13-7
Color Yellow
Purity Grade Notes Research
Molecular Formula C14H11NO5
Quantity 100 mg
Synonym Ro 40-7592
Solubility Information DMSO : 100 mg/mL (365.98 mM; Need ultrasonic)
SMILES O=C(C1=CC(O)=C(O)C([N+]([O-])=O)=C1)C2=CC=C(C)C=C2
Molecular Weight (g/mol) 273.24
Formula Weight 273.24
Percent Purity 95.0%
Grade Research
Physical Form Solid
For Use With (Application) Neuroscience-Neurodegeneration
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Research purposes only

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