Invitrogen™ TOB1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA565480

Product Code. 15958224

Description

Immunogen sequence: STKMKNSGRSN KVARTSPINL GLNVNDLLKQ KAISSSMHSL YGLGLGSQQQ PQQQ Highest antigen sequence identity to the following orthologs - mouse 91%, rat 91%.

This gene encodes a member of the tob/btg1 family of anti-proliferative proteins that have the potential to regulate cell growth. When exogenously expressed, this protein supresses cell growth in tissue culture. The protein undergoes phophorylation by a serine/threonine kinase, 90 kDa ribosomal S6 kinase. Interactions of this protein with the v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 gene product p185 interferes with growth suppression. This protein inhibits T cell proliferation and transcription of cytokines and cyclins. The protein interacts with both mothers against decapentaplegic Drosophila homolog 2 and 4 to enhance their DNA binding activity. This interaction inhibits interleukin 2 transcription in T cells.

Specifications

• Antigen: TOB1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: TOB1
• Gene Alias: APRO5; APRO6; MGC104792; MGC34446; PIG49; proliferation-inducing gene 49; protein Tob1; Protein Tob1-like protein; TOB; TOB1; transducer of erbB2; Transducer of erbB-2 1; transducer of ERBB2, 1; transducer of ErbB-2.1; Trob; TROB1; Unknown (protein for MGC:134447)
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 10140
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Immunocytochemistry
• Concentration: 0.1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: P50616
• Gene Symbols: TOB1
• Immunogen: Recombinant Human TOB1. Recombinant protein control fragment (Product #RP-106155).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG