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Invitrogen™ TNFR2 Monoclonal Antibody (22221.311)
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Product Code. 11534772
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Quantity:
100 μg
Unit Size:
100µg
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Product Code. Quantity unitSize
11534772 100 μg 100µg
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Product Code. 11534772 Supplier Invitrogen™ Supplier No. MA124723

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Description

Mouse Monoclonal Antibody

Recommended positive controls: human peripheral blood lymphocytes. In Neutralization studies, at 0.5-1.0 μg/mL, this antibody will block 50% of the bioactivity due to 0.3 μg/mL recombinant human sTNF RII, in the presence of 0.25 ng/mL TNF-alpha in a crystal violet cytolytic assay using mouse L929 cells. Anti-Human sTNF RII is tested for its ability to neutralize the biological effect of sTNF-RII but not sTNF RI in a cytolytic assay using mouse L929 cells, in the presence of TNF-alpha. The ND50 of the antibody is defined as the concentration of antibody resulting in a one-half maximal inhibition of the soluble receptor activity on a responsive cell line, when the soluble receptor is present at a concentration just high enough to elicit a maximum response. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

TNFR2 (tumor necrosis factor receptor superfamily member 1B) is a receptor with high affinity for TNFSF2/TNF-alpha. It has a much lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. TNFR2 mediates most of the metabolic effects of TNF-alpha.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TNFR2
Applications Flow Cytometry, Neutralization, Immunocytochemistry
Classification Monoclonal
Clone 22221.311
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 5% trehalose and no preservative
Gene Tnfrsf1b
Gene Accession No. P20333
Gene Alias CD120b; Etanercept; p75; p75 TNF receptor; p75 TNFR; p75TNFR; p80 TNF-alpha receptor; sCD120b; soluble CD120b; soluble TNFR1B variant 1; soluble TNFR2; sTNF R2; sTNFR 2; sTNFR2; TBP-2; TBPII; TNF receptor beta chain; TNF receptor superfamily member 1B; TNF-alphaR2; TNFalpha-R2; TNFBR; TNFR; TNFR II; Tnfr-1; TNFR1B; TNFR2; TNF-R2; Tnfr-2; TNF-R75; TNFR80; TNFRII; TNF-RII; TNF-R-II; TNFR-II; TNFRSF1B; tumor necrosis factor beta receptor; tumor necrosis factor binding protein 2; Tumor necrosis factor receptor; tumor necrosis factor receptor 2; Tumor necrosis factor receptor superfamily member 1B; Tumor necrosis factor receptor superfamily member 1b, membrane form; tumor necrosis factor receptor superfamily, member 1B; tumor necrosis factor receptor type II; Tumor necrosis factor-binding protein 2
Gene Symbols Tnfrsf1b
Host Species Mouse
Immunogen Recombinant human tumor necrosis factor receptor II, expressed in Escherichia coli.
Purification Method Purified
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 7133
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG2a
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