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Invitrogen™ TNF alpha Rat Uncoated ELISA Kit

Uncoated ELISA Kit

£309.00 - £441.00


Products 2
Product Code Brand Description Price Quantity & Availability  
Product Code Brand Description Price Quantity & Availability  
15591117
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Invitrogen™
88-7340-77
20 x 96 Tests
£441.00
Pack of 20
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Estimated Shipment
28-01-2021
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15511127
View Documents
Invitrogen™
88-7340-88
10 x 96 Tests
£309.00
Pack of 10
View alternative products
Save Up to 
»
Estimated Shipment
22-02-2021
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Description

Description

Tumor Necrosis Factor is a polypeptide cytokine produced by monocytes and macrophages. It functions as a multipotent modulator of immune response and further acts as a potent pyrogen. TNF-alpha circulates throughout the body responding to stimuli (infectious agents or tissue injury), activating neutrophils, altering the properties of vascular endothelial cells, regulating metabolic activities of other tissues, as well as exhibiting tumoricidal activity by inducing localized blood clotting. TNF-alpha also inhibits lipoprotein lipase activity resulting in cachexia, a physical wasting condition. Activation of B-cells by the Epstein Barr virus can be inhibited by TNF-alpha. Due to its varied actions throughout the immune system, TNF-alpha may play a role in the pathogenesis of many disease states. TNF-alpha production is mediated by the action of lymphokines and endotoxins on the macrophage. Purified monocytes produce TNF-alpha within four hours of stimulation by recombinant IL-2 and there is some in vitro evidence to suggest that TNF-alpha is expressed at high levels and with prolonged kinetics in T cells stimulated by both CD2 and CD28. Secretion of TNF-alpha is enhanced by gamma interferon. TNF then induces or enhances the specific production of Class I MHC antigen, GM-CSF, and IL-1.
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