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Invitrogen™ TMPRSS2 Monoclonal Antibody (CL12512)

Description
Highest antigen sequence identity to the following orthologs: Mouse - 66%, Rat - 66%.
TMPRSS2 is a protein that belongs to the serine protease family. The protein contains a type II transmembrane domain, a receptor class A domain, a scavenger receptor cysteine-rich domain and a protease domain. Serine proteases are known to be involved in many physiological and pathological processes. Its gene was demonstrated to be up-regulated by androgenic hormones in prostate cancer cells and down-regulated in androgen-independent prostate cancer tissue. The protease domain of this protein is thought to be cleaved and secreted into cell media after autocleavage.
Specifications
Specifications
| Antigen | TMPRSS2 |
| Applications | Immunohistochemistry (Paraffin) |
| Classification | Monoclonal |
| Clone | CL12512 |
| Concentration | 1.0 mg/mL |
| Conjugate | Unconjugated |
| Formulation | PBS with 40% glycerol and 0.02% sodium azide; pH 7.2 |
| Gene | TMPRSS2 |
| Gene Accession No. | O15393 |
| Gene Alias | D16Ertd61e; EC 3.4.219; epitheliasin; FLJ41954; MGC6821; Plasmic transmembrane protein X; PP9284; PRSS10; Serine protease 10; Tmprss2; TMPS2; Transmembrane protease serine 2; Transmembrane protease serine 2 catalytic chain; Transmembrane protease serine 2 non-catalytic chain; transmembrane protease, serine 2 |
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