Invitrogen™ TMP21 Polyclonal Antibody

Goat Polyclonal Antibody

Brand:  Invitrogen™ PA5142254

Product Code. 17846892

Description

This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:1,000.

TMP21 is a ubiquitously expressed protein that is involved in vesicular targeting and protein transport. More recent experiments have shown that it is also a component in the presenilin complex and modulates the -gamma-secretase but not the epsilon-secretase cleavage activity of the amyloid precursor protein. The presenilin complex is composed of the proteins APH1, nicastrin, and PEN2 in addition to presenilin-1. Together, these proteins cleave the amyloid precursor protein at what is known as the -gamma- and epsilon-sites and can lead to the accumulation of the Abeta cleavage product that is associated with Alzheimer's disease. Co-immunoprecipitation experiments using antibodies against these proteins also yielded TMP21 indicating that TMP21 may play a role in the regulation of this complex. Suppression of TMP21 expression by siRNA in transfected cells caused increased -gamma-secretase activity but not epsilon-secretase activity, and increased Abeta production, demonstrating that TMP21 can modulate -gamma-secretase activity.

Specifications

• Antigen: TMP21
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: TMED10
• Gene Alias: 1110014C03Rik; 21 kDa transmembrane trafficking protein; 21 kDa transmembrane-trafficking protein; hypothetical protein; integral membrane protein p23; integral membrane protein Tmp21-I (p23); p23; p24 family protein delta-1; P24(DELTA); p24d1; p24delta; p24delta1; S31I125; S31III125; testicular tissue protein Li 206; tmed10; tmed10.L; TMP21; Tmp-21-I; transmembrane emp24 domain-containing protein 10; transmembrane emp24-like trafficking protein 10; transmembrane emp24-like trafficking protein 10 (yeast); transmembrane p24 trafficking protein 10; transmembrane p24 trafficking protein 10 L homeolog; transmembrane protein; transmembrane protein tmp21; transmembrane trafficking protein; transmembrane trafficking protein 21; XELAEV_18000191mg; Xp24d2; Xp24delta2
• Host Species: Goat
• Purification Method: Ammonium sulfate precipitation
• Regulatory Status: RUO
• Gene ID (Entrez): 10972
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Flow Cytometry, Western Blot, Immunocytochemistry
• Concentration: 0.5 mg/mL
• Formulation: TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3
• Gene Accession No.: P49755
• Gene Symbols: TMED10
• Immunogen: Peptide with sequence C-YLRRFFKAKKLIE (aa 207-219).
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG