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Invitrogen™ TMEM66 Polyclonal Antibody
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Product Code. 13426117
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Quantity:
100 μL
Unit Size:
100µL
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13426117 100 μL 100µL
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Product Code. 13426117 Supplier Invitrogen™ Supplier No. PA531588

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Description

Rabbit Polyclonal Antibody

Recommended positive controls: 293T, Jurkat, Raji. Predicted reactivity: Mouse (85%), Rat (84%), Bovine (84%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Saraf encodes a protein that is a negative regulator of store-operated Ca(2+) entry (SOCE) involved in protecting cells from Ca(2+) overfilling. In response to cytosolic Ca(2+) elevation after endoplasmic reticulum Ca(2+) refilling, promotes a slow inactivation of STIM (STIM1 or STIM2)-dependent SOCE activity: possibly act by facilitating the de-oligomerization of STIM to efficiently turn off ORAI when the endoplasmic reticulum lumen is filled with the appropriate Ca(2+) levels, and thus preventing the overload of the cell with excessive Ca(2+) ions.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TMEM66
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 20% glycerol and 0.01% thimerosal; pH 7
Gene SARAF
Gene Accession No. Q96BY9
Gene Alias 1810045K07Rik; arrestin-E; FOAP-7; HBV XAg-transactivated protein 3; HBV X-transactivated gene 3 protein; HSPC035; NPD003; Protein FOAP-7; PSEC0019; Saraf; SARAF long isoform; SARAF short isoform; SOCE-associated regulatory factor; store-operated calcium entry associated regulatory factor; store-operated calcium entry-associated regulatory factor; testicular secretory protein Li 59; TMEM66; Transmembrane protein 66; UNQ1967/PRO4499; XTP3
Gene Symbols SARAF
Host Species Rabbit
Immunogen Recombinant protein encompassing a sequence within the center region of human TMEM66. The exact sequence is proprietary.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 51669
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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