TMEM59 Rabbit anti-Human, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Brand:  Proteintech 24134-1-AP-20UL

Product Code. 16882685

Description

Processing of the amyloid precursor protein (APP) by two different proteases, called alpha- and beta-secretase, is a central regulatory event in the generation of the amyloid beta peptide (Abeta), which has a key role in Alzheimer disease (AD) pathogenesis. TMEM59, a Golgi-localized protein, modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP. It inhibits APP transport and shedding.

Specifications

• Antigen: TMEM59
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: TMEM59
• Gene Alias: C1orf8, HSPC001, Liver membrane bound protein, TMEM59, transmembrane protein 59, UNQ169/PRO195
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 9528
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Immunocytochemistry, Western Blot, Immunofluorescence
• Concentration: 0.15 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: Q9BXS4
• Gene Symbols: TMEM59
• Immunogen: TMEM59 Fusion Protein Ag21150
• Quantity: 20 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG