Invitrogen™ TMEM52B Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA5144059

Product Code. 17901151

Description

Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL. Positive Control - WB: human 293T whole cell, monkey COS-7 whole cell, human SiHa whole cell, rat kidney tissue, rat NRK whole cell, mouse kidney tissue, mouse HBZY-1 whole cell. Flow: RT4 cell. Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

The TMEM52B gene encodes a transmembrane protein that is widely expressed across various normal human tissues, suggesting its fundamental role in maintaining cellular integrity. TMEM52B is part of the transmembrane protein (TMEM) family, which contains proteins that span biological membranes, including the lipid bilayer of the plasma membrane and organelle membranes. This gene is notably involved in tumor biology, where it modulates cancer cell survival and invasion. Studies have shown that suppression of TMEM52B expression can enhance the aggressiveness of cancer cells, indicating its potential as a tumor suppressor gene. Specifically, TMEM52B isoforms such as P18 and P20 have been found to differentially influence tumor dynamics, particularly in the context of nasopharyngeal carcinoma (NPC). While its exact molecular mechanisms remain largely unknown, the regulation of TMEM52B is crucial for controlling tumor growth and metastasis. Therefore, understanding its role could provide insights into therapeutic strategies aimed at curbing cancer progression.

Specifications

• Antigen: TMEM52B
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: TMEM52B
• Gene Alias: C12orf59; TMEM52B; Transmembrane protein 52B; UNQ5927/PRO19821
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 120939, 330428, 689963
• Content And Storage: -20°C
• Form: Lyophilized

• Applications: ELISA, Flow Cytometry, Western Blot
• Concentration: 500 μg/mL
• Formulation: PBS with 4mg trehalose and no preservative
• Gene Accession No.: Q0VBF2, Q4KMG9
• Gene Symbols: TMEM52B
• Immunogen: E.coli-derived human TMEM52B recombinant protein (Position: T22-N183).
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Monkey, Rat
• Product Type: Antibody
• Isotype: IgG