TMEM38A Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Product Code	Brand	Quantity
16859394	Proteintech 19920-1-AP-20UL	20 μL
16849394	Proteintech 19920-1-AP-150UL	150 μL

Description

TMEM38A and TMEM38B are two recently identified trimeric intracellular cation (TRIC) channel subtypes. TMEM38A is preferentially expressed in excitable tissues such as striated muscle and brain and localizes to the sarcoplasmic reticulum (SR) in muscle tissues. Mice deficient in both TMEM38A and TMEM38B suffer embryonic cardiac failure; the cardiac myocytes display severe dysfunction in SR Ca2+ handling, weakened Ca2+ release, and reduced K+ permeability indicating that the TRIC cation channels are likely to act as counter-ion channels that function in synchronization with Ca2+ release from intracellular stores. Other experiments have shown that TMEM38A and TMEM38B can act with junctophilin proteins to support efficient ryanodine receptor-mediated Ca2+ release in muscle cells.

Specifications

• Antigen: TMEM38A
• Applications: Western Blot
• Conjugate: Unconjugated
• Host Species: Rabbit
• Target Species: Human, Mouse, Rat
• Gene Accession No.: A6ZIQ8, Q3TMP8, Q9H6F2
• Gene ID (Entrez): 306327, 74166, 79041
• Immunogen: TMEM38A Fusion Protein Ag13846
• Primary or Secondary: Primary
• Content And Storage: -20°C
• Gene: TMEM38A

• Concentration: 0.45 mg/mL
• Classification: Polyclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Alias: TMEM38A, transmembrane protein 38A, TRICA, TRIC-A
• Gene Symbols: Tmem38a
• Isotype: IgG
• Purification Method: Antigen Affinity Chromatography
• Product Type: Antibody