Invitrogen™ TMEM259 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA531230

Product Code. 13435747

Description

Recommended positive controls: K562, THP-1, HL-60. Predicted reactivity: Mouse (84%), Rat (84%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Human membralin is unique and does not share significant sequence homology with other human genes, only membralins of other species. The membralin gene contains 11 exons which encode at least two spliced variants in human cancer. The long form of membralin (membralin-1) comprises all 11 exons, encoding a protein of 620-amino acids long and the short form of membralin (membralin-3) contains all exons except for exon 10, encoding a protein of 408 amino acids. Expression of different membralin isoforms depends on tissue type. The long form, membralin-1, is expressed in ovarian and colorectal carcinomas but not in breast or pancreatic carcinomas, which express only the short splice form, membralin-3. Recent studies suggest that membralin is a novel tumor-associated marker in ovarian serous carcinomas.

Specifications

• Antigen: TMEM259
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: TMEM259
• Gene Alias: AC087114.7gm2; ASBABP1; aspecific BCL2 ARE-binding protein 1; C19orf6; C20H19orf6; im:7154960; MBRL; MEMBRALIN; mFLJ00277; ORF61; R32184_3; RGD1311136; TMEM259; Transmembrane protein 259
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 91304
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 1% BSA, 20% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: Q4ZIN3
• Gene Symbols: TMEM259
• Immunogen: Recombinant protein encompassing a sequence within the center region of human Membralin. The exact sequence is proprietary.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG