Invitrogen™ TMEM24 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA5145107

Product Code. 18076351

Description

Immunogen sequence: LIISGVSKVP IAQDELALSL GYAASLEASV QDDAGTSGGP SSPPSDPPAM SPGPLDALSS PTSVQEADET TRSDISERPS VDDIESET Antigen sequence identity: Mouse 94%; Rat 93%.

Lipid-binding protein that transports phosphatidylinositol, the precursor of phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), from its site of synthesis in the endoplasmic reticulum to the cell membrane (PubMed:28209843). It thereby maintains the pool of cell membrane phosphoinositides, which are degraded during phospholipase C (PLC) signaling (PubMed:28209843). Plays a key role in the coordination of Ca(2+) and phosphoinositide signaling: localizes to sites of contact between the endoplasmic reticulum and the cell membrane, where it tethers the two bilayers (PubMed:28209843). In response to elevation of cytosolic Ca(2+), it is phosphorylated at its C-terminus and dissociates from the cell membrane, abolishing phosphatidylinositol transport to the cell membrane (PubMed:28209843). Positively regulates insulin secretion in response to glucose: phosphatidylinositol transfer to the cell membrane allows replenishment of PI(4,5)P2 pools and calcium channel opening, priming a new population of insulin granules (PubMed:28209843). [UniProt].

Specifications

• Antigen: TMEM24
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: C2CD2L
• Gene Alias: 1300006O23Rik; C2 calcium-dependent domain containing 2-like; C2 domain-containing protein 2-like; C2 domain-containing protein 2-like; phospholipid transfer protein C2CD2L; c2cd2 like; C2cd2l; C2CD2-like; DLNB23; KIAA0285; Phospholipid transfer protein C2CD2L; tmem24; Transmembrane protein 24; zgc:153961
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 9854
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid
• Isotype: IgG

• Applications: Immunocytochemistry, Western Blot
• Concentration: 0.05 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: O14523
• Gene Symbols: C2CD2L
• Immunogen: Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence. Antigen range: 534-621. Recombinant protein control fragment (Product #a href=.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Format: Liquid