Invitrogen™ TMEM2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA569170

Product Code. 15827583

Description

This target displays homology in the following species: Cow: 100%; Dog: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 85%; Rabbit: 100%; Rat: 100%.

This gene encodes a type II transmembrane protein that belongs to the interferon-induced transmembrane (IFITM) protein superfamily. The encoded protein functions as a cell surface hyaluronidase that cleaves extracellular high molecular weight hyaluronan into intermediate size fragments before internalization and degradation in the lysosome. It also has an interferon-mediated antiviral function in humans through activation of the JAK STAT signaling pathway. The activation of this gene by transcription factor SOX4 in breast cancer cells has been shown to mediate the pathological effects of SOX4 on cancer progression. Naturally occurring mutations in this gene are associated with autosomal recessive non-syndromic hearing loss.

Specifications

• Antigen: TMEM2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CEMIP2
• Gene Alias: basic helix-loop-helix domain containing, class B, 2; BHLHB2; cell migration inducing hyaluronidase 2; Cell migration-inducing hyaluronidase 2; Cell surface hyaluronidase; CEMIP2; Kiaa1412; Tmem2; transmembrane protein 2
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 83921
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Western Blot
• Concentration: 0.5 mg/mL
• Formulation: PBS with 2% sucrose and 0.09% sodium azide
• Gene Accession No.: Q5FWI3
• Gene Symbols: CEMIP2
• Immunogen: synthetic peptide directed towards the middle region of human TMEM2 (aa 1-50).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Mouse
• Product Type: Antibody
• Isotype: IgG