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Invitrogen™ TMEM18 Polyclonal Antibody

Product Code. 12848832
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Quantity:
100 μg
Unit Size:
100µg
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12848832 100 μg 100µg
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Product Code. 12848832 Supplier Invitrogen™ Supplier No. PA520689

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Description

Rabbit Polyclonal Antibody

A suggested positive control is rat brain tissue lysate. PA5-20689 can be used with blocking peptide PEP-0804.

Recent studies have examined how overexpression of certain genes enhances the tropism of neural stem cells (NSCs) for gliomas. Overexpression of Transmembrane protein 18 (TMEM18) provides NSCs and neural precursors an increased migration capacity towards glioblastoma cells in vitro and in the rat brain, while functional inactivation of the gene resulted in an almost complete loss of migration activity, suggesting that TMEM18 could be a potential target in NSC-based glioma therapy. Other recent results suggest that among others, the TMEM18 loci is associated with higher than normal body mass index (BMI) and obesity, indicating there may be a CNS-related role in predisposition to obesity. Multiple isoforms of TMEM18 are known to exist.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TMEM18
Applications Immunohistochemistry, Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene TMEM18
Gene Accession No. Q3TUD9, Q6DGF8, Q96B42
Gene Alias BC024093; TMEM18; Transmembrane protein 18
Gene Symbols TMEM18
Host Species Rabbit
Immunogen A 15 amino acid peptide near the carboxy terminus of human TMEM18.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 129787, 211986, 362722
Target Species Human, Mouse, Rat
Content And Storage Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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