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Invitrogen™ TMC6 Polyclonal Antibody

Product Code. 12848682
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Quantity:
100 μg
Unit Size:
100µg
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12848682 100 μg 100µg
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Product Code. 12848682 Supplier Invitrogen™ Supplier No. PA520504

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Description

Rabbit Polyclonal Antibody

A suggested positive control is A-20 cell lysate. PA5-20504 can be used with blocking peptide PEP-0624.

TMC6 interacts with, and forms a complex with the zinc transporter 1, SLC30A1, and localizes to the endoplasmic reticulum, nuclear membrane and Golgi apparatus. The inactivation of the TMC6 gene has been implicated in the skin disorder epidermodysplasia verruciformis (EV), an autosomal recessive dermatosis characterized by abnormal susceptibility to human papillomaviruses (HPVs) and a high rate of progression to squamous cell carcinoma on sun-exposed skin. EV is caused by mutations in either of two adjacent genes located on chromosome 17q25.3. TMC6 encodes integral membrane proteins that localize to the endoplasmic reticulum and are predicted to form transmembrane channels. This gene encodes a transmembrane channel-like protein with 10 transmembrane domains and 2 leucine zipper motifs. Diseases associated with TMC6 include Epidermodysplasia Verruciformis and Superficial Mycosis.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TMC6
Applications Immunohistochemistry, Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene TMC6
Gene Accession No. Q7TN60, Q7Z403
Gene Alias D11Ertd204e; epidermodysplasia verruciformis 1; epidermodysplasia verruciformis protein 1; EV1; EVER1; EVIN1; expressed in activated T/LAK lymphocytes; LAK-4P; protein LAK-4; Tmc6; transmembrane channel like 6; transmembrane channel-like gene family 6; transmembrane channel-like protein 6
Gene Symbols TMC6
Host Species Rabbit
Immunogen A 14 amino acid peptide from near the amino terminus of human EVER1.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 11322, 217353, 688280
Target Species Human, Mouse, Rat
Content And Storage Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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