Invitrogen™ TMC6 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA520504

Product Code. 12848682

Description

A suggested positive control is A-20 cell lysate. PA5-20504 can be used with blocking peptide PEP-0624.

TMC6 interacts with, and forms a complex with the zinc transporter 1, SLC30A1, and localizes to the endoplasmic reticulum, nuclear membrane and Golgi apparatus. The inactivation of the TMC6 gene has been implicated in the skin disorder epidermodysplasia verruciformis (EV), an autosomal recessive dermatosis characterized by abnormal susceptibility to human papillomaviruses (HPVs) and a high rate of progression to squamous cell carcinoma on sun-exposed skin. EV is caused by mutations in either of two adjacent genes located on chromosome 17q25.3. TMC6 encodes integral membrane proteins that localize to the endoplasmic reticulum and are predicted to form transmembrane channels. This gene encodes a transmembrane channel-like protein with 10 transmembrane domains and 2 leucine zipper motifs. Diseases associated with TMC6 include Epidermodysplasia Verruciformis and Superficial Mycosis.

Specifications

• Antigen: TMC6
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: TMC6
• Gene Alias: D11Ertd204e; epidermodysplasia verruciformis 1; epidermodysplasia verruciformis protein 1; EV1; EVER1; EVIN1; expressed in activated T/LAK lymphocytes; LAK-4P; protein LAK-4; Tmc6; transmembrane channel like 6; transmembrane channel-like gene family 6; transmembrane channel-like protein 6
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 11322, 217353, 688280
• Content And Storage: Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
• Form: Liquid

• Applications: Immunohistochemistry, Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 0.02% sodium azide
• Gene Accession No.: Q7TN60, Q7Z403
• Gene Symbols: TMC6
• Immunogen: A 14 amino acid peptide from near the amino terminus of human EVER1.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG